Spider-man must team up with his old enemy Venom to investigate the disappearances of both the police and also of armed criminals. There search takes them to the sewer where they find something that nothing could ever prepare them for...

He's been seen as prey plenty of times before, all by deranged peaple. But now a new hunter has his sights set on the wall-crawler, one who has experienced hunting humans and the abnormal.

After a battle between Spiderman and one of his villians releases a threat that may just wipe out the entire world, it comes down to the Webslinger to put a stop to it. But is he in over his head?