After leaving Aperture Chell finds herself in Rome, times are much different now and it seems the city is controlled by the Borgia family, in a city littered with evil she has no one to turn to. Until she meets Ezio and the Assassin Order.

Ezio encounters a strange new citizen in Rome. Her elusive behavior makes him suspicious and he tries to discover exactly who she is and how she escapes him so easily. Takes place in AC:Brotherhood and just after Portal 2; major spoilers.