President James Whitmore calls his friend, Robert T. Ironside to investigate the murder of his wife in the White House but finds he also needs his brother, Perry Mason when he is accused of the crime.

Hamilton Burger has been charged with murder. With Paul Drake on vacation in Europe and unavailable, Perry Mason enlists the help of Chief Robert T. Ironside to do the investigation to help clear the Los Angeles District Attorney.

Perry Mason and Robert T. Ironside's vacation is interrupted by a man intent on taking revenge on the San Francisco Detective. They must find a way to protect themselves until they can get word to their friends for help

Commissioner Dennis Randall is accused of killing a drug dealer who is responsible for the drug overdose death of his niece. Ironside turns to Perry Mason to defend his longtime friend. The two again join forces to clear Randall of murder.

Perry and Della travel to San Franciso to defend a young man accused of killing a cop. Perry finds he must either butt heads with San Franciso's famous detective, Chief Robert T. Ironside or enter into an unusual alliance with him.