Five months have passed since "Omega Kapu". While on vacation to Honolulu, Lilo, Stitch, and the others have to rescue Earth's leaders and liberate the Island of Oahu from the clutches of General Rew'Ghar and a mysterious shadow villainess.

6 months have passed since Lilo & Stitch rescued their ohana from Hamsterviel. Now Hamsterviel has hired two new henchmen to construct the ultimate weapon. Lilo soon learns a terrible truth about the two villains. Can Lilo & Stitch thwart this new threat?

Rueben and Kaikoo, Gantu's young son escape fro Hamsterviel's ship but land on Earth where an old friend helps them try to find the ohana but shows them they can be ohana to each other and feel they belong but Hamsterviel still wants the entire galaxy...

Lilo & Stitch have finally re-united and eventually admitted their true feelings for each other. But, when the evil Dr. Jacques von Hamsterviel returns, the new couple, along with old and new friends, set out to save their ohana and the galaxy.