Prologue: May 26, 2017.

The 'Miami Zombie' bath salt incident is now 5 years old. Once again, zombies are in the news. However, this time, it isn't a guy hopped up on drugs. This is the Green Flu.

After the initial outbreaks in Pennsylvania, it didn't take long for the largest city in the United States to fall into chaos too. New York turned into chaos barely 2 weeks after the infection started. Thousands of infected swarm the streets, while unsuspecting and best friends, Brian Quinn, James Murray, Joe Gatto, and Salvatore Vulcano.

In this somewhat sensible crossover between Impractical Jokers and Left 4 Dead, the crew fight their way through New York City, unsure if the Tenderloins can make it out alive.