Stupid humans! He likes humanity as a species. They are adventurous, resourceful, and endlessly curious. But some humans just don't measure up. Like Mia. He rescues her in his magnificent TARDIS, and takes her home on the same day she left Mars. What does the foolish girl do? Runs away without even a 'thanks for the lift, Doctor'.
Still, it's Adelaide who really infuriates him. All that intelligence, courage, and potential, and she wastes it. How dare she throw away the life he so generously gave her? Ingratitude and arrogance -- and he can't decide which is the greater sin.