One day Carlisle received a letter. It said that his old friend dr Wilbur had died from an overdose and that his son Homer was having a little trouble taking care of all the orphans on his own. So he asked Carlisle if he could come to Alabama when it was time for the Cullens to move again, and help out. Carlisle and Esme had adopted several orphans themselves, and felt sympathetic to the cause.
Unfortunately one of their adopted childre, Jasper didn't quite control his lust for human blood, so he bit a lot of the orphans. This made things very difficult for them, since peolpe in Alabama have prejudices agains vampires and orphans.
So they had to move out of the old orphanage and live on an old farm far from other people, where they grew vegetables and fruit for income.