Set two weeks after the events of Resident Evil 4: A certain government agent is now carrying a bullseye on his back. Albert Wesker wants Leon dead. And Ada's true goals will be challenged as she is forced to make a choice.

Two months after her successful acquisition of the Master Plaga sample in Spain, Ada Wong finds herself in Washington, D.C. to warn Leon about the danger that still stalks him. However, what she finds when she enters his apartment will shock her to her very core concerning the man's feelings when it comes to her.

Set before the events in Resident Evil 5, Leon S. Kennedy is busy working on a report for Chris Redfield when he receives a mysterious call from an old friend.